Pyrrolidine → HCID 69497328, compound

HRID 1242906Notes

Reaction equation

HRID 1242906 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[C:10](=[CH:16][N:17]([CH3:19])[CH3:18])[CH2:9][CH2:8]2)(=[O:3])[CH3:2].N1CC[CH2:22][CH2:21]1>>[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[C:10](=[CH:16][N:17]1[CH2:18][CH2:22][CH2:21][CH2:19]1)[CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 57373319HCID 57373319, compound

Product 1

HCID 69497328HCID 69497328, compound

Procedure

6-Acetylamino-2-[(dimethylamino)methylidene]-1-tetralone (4.90 g, 0.017 mol) obtained in Example 41-1) was suspended in pyrrolidine (25 ml), which was refluxed with heating for 2 hours. The crystallized product was collected by filtration, washed with a mixed solution of ethyl acetate and n-hexane (1:1), to give 6-acetylamino-2-(1-pyrrolidinylmethylidene)-1-tetralone (5.03 g) as yellow crystals.

Workup

  1. temperaturewhich was refluxed
  2. temperaturewith heating for 2 hours
  3. filtrationThe crystallized product was collected by filtration
  4. washwashed with a mixed solution of ethyl acetate and n-hexane (1:1)

Sources & evidence

ORD record
ord-df244104fec149df9df477f2a651d226
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

Loading…