反应详情

温度

120 °C

6-Cyano-1-tetralone (1.30 g, 7.59 mmol) synthesized by a known literature method (Synthetic Communications, 23(21), 2965 (1993)) was dissolved in a mixed solution of concentrated hydrochloric acid (10 ml) and acetic acid (20 ml), which was stirred at 120° C. for 16 hours. The reaction mixture was concentrated. Ethyl acetate and water were added to the residue, and extraction was conducted. The organic layer was washed with water, and concentrated. The residue was washed with ethyl acetate-n-hexane (1:1), to give 5-oxo-5,6,7,8-tetrahydro-2-naphthalenecarboxylic acid (1.10 g) as a white powder.

1. concentrationThe reaction mixture was concentrated
2. additionEthyl acetate and water were added to the residue, and extraction
3. washThe organic layer was washed with water
4. concentrationconcentrated
5. washThe residue was washed with ethyl acetate-n-hexane (1:1)