HCID 21940017, compound → HCID 69497291, compound

HRID 1242938Notes

Reaction equation

HRID 1242938 reaction equation
[ClH:1].[NH:2]1[CH2:6][CH2:5][N:4]=[C:3]1/[CH:7]=[CH:8]/[C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[O:17])=[CH:11][CH:10]=1>[C].[Pd].CO>[ClH:1].[NH:4]1[CH2:5][CH2:6][N:2]=[C:3]1[CH:7]=[CH:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:20][CH:19]=2)=[O:17])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 21940017HCID 21940017, compound

Product 1

HCID 69497291HCID 69497291, compoundYield 65%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

10% Palladium—carbon (200 mg) was added to a methanol suspension of N-[4-[(E)-2-(4,5-dihydro-1H-imidazol-2-yl)ethenyl]phenyl][1,1′-biphenyl]-4-carboxamide hydrochloride (80 mg, 0.198 mmol) obtained in Example 124, which was stirred under hydrogen atmosphere at 60° C. for 2 hours. After a catalyst was filtered off, the solvent was distilled out under reduced pressure. Diethyl ether was added to the resulting residue, to give the titled compound (52 mg) as a colorless powder.

Workup

  1. filtrationAfter a catalyst was filtered off
  2. distillationthe solvent was distilled out under reduced pressure
  3. additionDiethyl ether was added to the resulting residue

Sources & evidence

ORD record
ord-4e0ae7f19229406fa1e275402438b4d2
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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