Hydrogen chloride-ethyl acetate → HCID 21939955, compound

HRID 1242942Notes

Reaction equation

HRID 1242942 reaction equation
C(OCC)(=O)C.[ClH:7].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][C:24]3[CH:43]=[CH:42][C:27]([CH2:28][CH:29]4[CH2:34][CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30]4)=[CH:26][CH:25]=3)=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[ClH:7].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:43]=[CH:42][C:27]([CH2:28][CH:29]4[CH2:34][CH2:33][CH2:32][NH:31][CH2:30]4)=[CH:26][CH:25]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21939733HCID 21939733, compound

Product 1

HCID 21939955HCID 21939955, compound

Procedure

4N Hydrogen chloride-ethyl acetate (3 ml) was added to tert-butyl 3-[4-[[(4′-fluoro[1,1′-biphenyl]-4-yl)carbonyl]amino]benzyl]-1-piperidinecarboxylate (150 mg, 0.307 mmol) obtained in Reference Example 81. Two hours later, the solvent was distilled out under reduced pressure. Diisopropyl ether was added to the residue, to give the titled compound (115 mg) as a colorless powder.

Workup

  1. customobtained in Reference Example 81
  2. distillationTwo hours later, the solvent was distilled out under reduced pressure
  3. additionDiisopropyl ether was added to the residue

Sources & evidence

ORD record
ord-a139fcd609c7403a8fda87ebd14767b0
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

Loading…