Hydrogen chloride-ethyl acetate → HCID 21939994, compound

HRID 1242943Notes

Reaction equation

HRID 1242943 reaction equation
C(OCC)(=O)C.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][C:24]3[CH:43]=[CH:42][C:27]([CH2:28][CH:29]4[CH2:34][CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30]4)=[CH:26][CH:25]=3)=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[ClH:8].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:43]=[CH:42][C:27]([CH2:28][CH:29]4[CH2:34][CH2:33][CH2:32][NH:31][CH2:30]4)=[CH:26][CH:25]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 21939960HCID 21939960, compound

Product 1

HCID 21939994HCID 21939994, compoundYield 111.8%

Procedure

4N Hydrogen chloride-ethyl acetate (3 ml) was added to tert-butyl 3-[4-[[(4′-chloro[1,1′-biphenyl]-4-yl)carbonyl]amino]benzyl]-1-piperidinecarboxylate (150 mg, 0.297 mmol)obtained in Reference Example 82. Two hours later, the solvent was distilled out under reduced pressure. Diisopropyl ether was added to the residue, to give the titled compound (73.3 mg) as a colorless powder.

Workup

  1. customobtained in Reference Example 82
  2. distillationTwo hours later, the solvent was distilled out under reduced pressure
  3. additionDiisopropyl ether was added to the residue

Sources & evidence

ORD record
ord-09c0f401dccf4ef08eee24ddf51b384b
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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