HCID 9865843, compound → HCID 21939983, compound

HRID 1242944Notes

Reaction equation

HRID 1242944 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][C:17]3[CH:26]=[CH:25][C:24]4[CH2:23][CH:22]([CH2:27][N:28]([CH3:30])[CH3:29])[CH2:21][CH2:20][C:19]=4[CH:18]=3)=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[ClH:31].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:31].[CH3:30][N:28]([CH2:27][CH:22]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([NH:16][C:14]([C:11]3[CH:12]=[CH:13][C:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)=[CH:9][CH:10]=3)=[O:15])[CH:26]=[CH:25][C:24]=2[CH2:23]1)[CH3:29]

Participants

4

Reactant 2

HCID 9865843HCID 9865843, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 21939983HCID 21939983, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4′-Fluoro-N-[6-[(N,N-dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl)[1,1′-biphenyl]-4-carboxamide synthesized in Example 42 was dissolved in ethyl acetate. An excess amount of 4N hydrochloric acid-ethyl acetate solution was added to the solution, which was concentrated under reduced pressure. The resulting residue was recrystallized from methanol-ethyl acetate, to give the titled compound.

Workup

  1. concentrationwas concentrated under reduced pressure
  2. customThe resulting residue was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-e6fc9cd576054fef963a7ef35ff18e47
Source dataset
uspto-grants-2006_10
Patent number
US07115750B1

Reaction notes

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