Acetanilide → HCID 16640263, compound

HRID 1242981Notes

Reaction equation

HRID 1242981 reaction equation
Br[C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[C:7]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:9])[CH3:8]>>[C:11]1([N:10]([C:2]2[CH:6]=[CH:5][S:4][CH:3]=2)[C:7](=[O:9])[CH3:8])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 904AcetanilideHCID 133833-Bromothiophene

Product 1

HCID 16640263HCID 16640263, compoundYield 82%

Procedure

Using general procedure C, 3-bromothiophene was coupled with acetanilide with the reaction time of 15 h. Chromatography gave 178 mg (82%) of the title compound as an oil. 1H NMR (CDCl3, 300 MHz): δ 7.44 (br s, 3H), 7.28 (s, 2H), 7.18 (s, 2H), 6.94 (d, 1H, J=4.8 Hz), 1.99 (br s, 3H).

Sources & evidence

ORD record
ord-edb7007156b64b1fbd9bf792837795fe
Source dataset
uspto-grants-2006_10
Patent number
US07115784B2

Reaction notes

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