Hexylamine → HCID 9964411, compound

HRID 1243098Notes

Reaction equation

HRID 1243098 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH3:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH2:10]([NH2:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[CH2:10]([NH:16][C:2]1[CH:3]=[C:4]([CH3:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1)[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 8102HexylamineHCID 136357Benzene, 1-bromo-3,5-dimethyl-

Product 1

HCID 9964411HCID 9964411, compoundYield 91.1%

Procedure

Using the general procedure, 5-bromo-m-xylene (136 μL, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol). Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (20:1) as eluent afforded the desired product as a colorless oil (187 mg, 91% yield).

Workup

  1. customPurification of the crude product by column chromatography on silica gel

Sources & evidence

ORD record
ord-1cc02c708c6c4b069f1c1270ec3034a2
Source dataset
uspto-grants-2006_10
Patent number
US07115784B2

Reaction notes

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