Hexylamine → HCID 9964251, compound

HRID 1243119Notes

Reaction equation

HRID 1243119 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[CH2:8]([NH2:14])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:8]([NH:14][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 8102HexylamineHCID 122863-Bromopyridine

Product 1

HCID 9964251HCID 9964251, compoundYield 82%

Procedure

Using the general procedure, 3-bromopyridine (96 μL, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol) at 90° C. for 18 h. Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (1:1) as eluent afforded the desired product as a colorless oil (146 mg, 82% yield). Rf=0.2 (hexane/ethyl acetate=2:1).

Workup

  1. customPurification of the crude product by column chromatography on silica gel

Sources & evidence

ORD record
ord-fd085eb276d2469c80aeb86f2719105a
Source dataset
uspto-grants-2006_10
Patent number
US07115784B2

Reaction notes

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