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Triethylamine → 8-Hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (4-diethylamino-phenyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N,N-Diethyl-p-phenylenediamine sulfate | HCID 80166 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | 8-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid | HCID 21940433 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-Hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (4-diethylamino-phenyl)-amide | HCID 44391342 | 62% |
反応手順
This phenol from Example 6A was dissolved in DMF (4.0 mL) and N,N-Diethyl-benzene-1,4-diamine sulfate (602 mg, 2.3 mmol), Et3N (707 mg, 7.0 mmol), and TBTU (738 mg, 2.3 mmol) were added at ambient temperature. The mixture was stirred overnight and purified by silica gel column chromatography to provide 8-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (4-diethylamino-phenyl)-amide (480 mg, 62%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07115767B2 |
| 出典データセット | uspto-grants-2006_10 |
| ORD ID | ord-a4a07c33681b43c49a2f29681394d0f9 |
| 出典メモ | uspto-grants-2006_10 |