反应详情

(2-(4-Diethylamino-phenylcarbamoyl)-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid tert-butyl ester from Example 3 (320 mg) was dissolved in dichloromethane (10 mL) and TFA (5.0 mL). The volatiles were removed after 2 h. The amine-TFA salt was then dissolved in ethyl acetate (30 mL) and washed with 1 N NaOH. The organic phase was dried over MgSO4 and purified by column chromatography to provide the titled compound (240 mg, 97%).

1. customThe volatiles were removed after 2 h
2. dissolutionThe amine-TFA salt was then dissolved in ethyl acetate (30 mL)
3. washwashed with 1 N NaOH
4. dry with materialThe organic phase was dried over MgSO4
5. custompurified by column chromatography