HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1243147Generated: October 25, 2026
1,4-Dioxane → 2-(Isobutoxycarbonyl-methyl-amino)-8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid
https://huagongshe.com/reaction/1243147
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 2-(Isobutoxycarbonyl-methyl-amino)-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid tert-butyl ester | HCID 69585104 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-(Isobutoxycarbonyl-methyl-amino)-8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid | HCID 21940431 | — |
Reaction Steps
The t-butyl ester from Example 33E was dissolved in 4 N HCl in dioxane (10 mL) and the resulting mixture was stirred at r.t for 16 h and at 60° C. for 1.5 h. The volatiles were removed to give the titled acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07115767B2 |
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| Source dataset | uspto-grants-2006_10 |
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| ORD ID | ord-21a4246168e546ad89ed33d9ebdc6ae1 |
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| Source note | uspto-grants-2006_10 |
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