1,4-Dioxane → 2-(Isobutoxycarbonyl-methyl-amino)-8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

HRID 1243147Notes

Reaction equation

C([O:5][C:6]([C:8]1([N:18]([C:20]([O:22][CH2:23][CH:24]([CH3:26])[CH3:25])=[O:21])[CH3:19])[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9]1)=[O:7])(C)(C)C.[O:27]1CCOC[CH2:28]1>Cl>[CH2:23]([O:22][C:20]([N:18]([CH3:19])[C:8]1([C:6]([OH:5])=[O:7])[CH2:17][CH2:16][C:15]2[C:10](=[C:11]([O:27][CH3:28])[CH:12]=[CH:13][CH:14]=2)[CH2:9]1)=[O:21])[CH:24]([CH3:25])[CH3:26]

Participants

Conditions

Temperature: 60 °C

Procedure

The t-butyl ester from Example 33E was dissolved in 4 N HCl in dioxane (10 mL) and the resulting mixture was stirred at r.t for 16 h and at 60° C. for 1.5 h. The volatiles were removed to give the titled acid.

Workup

customThe volatiles were removed

Sources & evidence

ORD record: ord-21a4246168e546ad89ed33d9ebdc6ae1
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07115767B2

Reaction notes

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