2-Bromopyridine → 1-(PYRIDIN-2-YL)-1,4-DIAZEPANE

HRID 1243328Notes

Reaction equation

HRID 1243328 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 79732-BromopyridineHCID 68163Hexahydro-1,4-diazepine

Product 1

HCID 27724021-(PYRIDIN-2-YL)-1,4-DIAZEPANE

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-bromopyridine and 12 g of homopiperazine is heated at 100° C. for 6 hours. 50 ml of water are added to the reaction mixture and the resulting mixture is extracted with EtOAc, the organic phase is washed with saturated NaCl solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 1.28 g of the expected product are obtained.

Workup

  1. extractionthe resulting mixture is extracted with EtOAc
  2. washthe organic phase is washed with saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customthe solvent is evaporated off under vacuum

Sources & evidence

ORD record
ord-6e8e0d76255349c9aaacd4e64da19443
Source dataset
uspto-grants-2006_10
Patent number
US07119086B2

Reaction notes

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