反应详情

A mixture of 13.52 g of tert-butyl 1-piperazinecarboxylate, 10.81 g of 3,6-dichloropyridazine and 20 ml of triethylamine in 100 ml of n-butanol is refluxed for 5 hours. The mixture is concentrated under vacuum and the residue is chromatographed on silica gel, eluting with a DCM/EtOAc mixture (90/10; v/v). 14 g of the expected product are obtained, and are used without further purification.

1. temperatureis refluxed for 5 hours
2. concentrationThe mixture is concentrated under vacuum
3. customthe residue is chromatographed on silica gel
4. washeluting with a DCM/EtOAc mixture (90/10; v/v)