Ammonium Hydroxide → 2-Oxoindoline-5-sulfonamide

HRID 1243374Notes

Reaction equation

HRID 1243374 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[OH-].[NH4+:16]>C(O)C>[NH2:16][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 49625062-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

Product 1

HCID 101982322-Oxoindoline-5-sulfonamideYield 20%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Chlorosulfonyl-2-oxindole (2.1 g) was added to 10 mL of ammonium hydroxide in 10 mL of ethanol and stirred at room temperature overnight. The mixture was concentrated and the solid collected by vacuum filtration to give 0.4. g (20% yield) of the title compound as an off-white solid.

Workup

  1. concentrationThe mixture was concentrated
  2. filtrationthe solid collected by vacuum filtration
  3. customto give 0.4

Sources & evidence

ORD record
ord-739f6aaa015f4250ad68c98f3bb4737d
Source dataset
uspto-grants-2006_10
Patent number
US07119090B2

Reaction notes

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