反应详情

4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (90 mg), 106 mg 5-bromo-2-oxindole, and 75 μL piperidine in 2 mL ethanol were heated to 95° C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 2 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven to give 120 mg (64%) of the title compound as a brown solid.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated
3. filtrationThe precipitate was filtered
4. washwashed with water to pH 6
5. customdried in a vacuum oven