反应详情

3-(2-carboxyethyl)-2,4-dimethyl-5-formylpyrrole (82 mg), 63 mg 6-hydroxy-2-oxindole, and 48 μL piperidine in 2 mL of ethanol were heated at 90° C. for two days. The reaction mixture was cooled, concentrated, and purified by silica gel column chromotography eluting with ethyl acetate-hexane-acetic acid to give 55 mg (40%) of the title compound as an dark brown solid.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated
3. custompurified by silica gel column chromotography
4. washeluting with ethyl acetate-hexane-acetic acid