反应详情

3-(2-Carboxyethyl)-2,4-dimethyl-5-formylpyrrole (3.3 g), 4 g 6-(morpholin-4-yl)-2-oxindole and 1.8 mL piperidine in 60 mL of ethanol were heated at 90° C. for 7 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven overnight. The resulting solid was purified by chromatography on a silica gel column eluting with ethyl acetate-hexane-acetic acid to give 2.78 g (38% yield) of the title compound as a brown solid.

1. temperatureThe reaction mixture was cooled
2. concentrationconcentrated
3. filtrationThe precipitate was filtered
4. washwashed with water to pH 6
5. customdried in a vacuum oven overnight
6. customThe resulting solid was purified by chromatography on a silica gel column
7. washeluting with ethyl acetate-hexane-acetic acid