反应详情

3,4,5,6-Tetrahydro-2H-[1,2′]bipyridinyl-4–Carboxylic acid ethyl ester (1 g, 4.3 mmol)(see reference Farmaco, 1993, 48(10), 1439) was dissolved in methanol (20 ml) containing hydrazine hydrate (620 μl, 20 mmol) and was heated under reflux for 18 hours. The mixture was cooled to room temperature and evaporated under reduced pressure. The solid formed was triturated with propan-2-ol to give the title compound as a white solid (493 mg).

1. temperaturewas heated
2. temperatureunder reflux for 18 hours
3. customevaporated under reduced pressure
4. customThe solid formed
5. customwas triturated with propan-2-ol