5-(Trifluoromethyl)-1,3-oxazol-2-amine → rac-4-fluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide

HRID 1243626Notes

Reaction equation

HRID 1243626 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[O:7][C:6]([NH2:8])=[N:5][CH:4]=1.[F:11][C:12]1[C:25]2[O:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]([C:26](O)=[O:27])[C:16]=2[CH:15]=[CH:14][CH:13]=1>>[F:1][C:2]([F:10])([F:9])[C:3]1[O:7][C:6]([NH:8][C:26]([CH:17]2[C:16]3[CH:15]=[CH:14][CH:13]=[C:12]([F:11])[C:25]=3[O:24][C:23]3[C:18]2=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:27])=[N:5][CH:4]=1

Participants

3

Reactant 2

HCID 219286275-(Trifluoromethyl)-1,3-oxazol-2-amineHCID 21928630(RS)-4-fluoro-9-xanthene-carboxylic acid

Product 1

HCID 10362260rac-4-fluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide

Procedure

The title compound, white solid, m.p. 228° C. and MS: m/e=379.2 (M+H+) is prepared in accordance with the general method of example 3c from 5-trifluoromethyl-oxazol-2-ylamine and (RS)-4-fluoro-9-xanthene-carboxylic acid.

Sources & evidence

ORD record
ord-fd9850b876154aeda03c212164707780
Source dataset
uspto-grants-2006_10
Patent number
US07119113B2

Reaction notes

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