(2-(Trifluoromethoxy)phenyl)methanamine → 5-Bromo-2-(4-chloro-benzenesulfonylamino)-N-(2-trifluoromethoxy-benzyl)-benzamide

HRID 1243657Notes

Reaction equation

HRID 1243657 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].[F:22][C:23]([F:34])([F:33])[O:24][C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH2:27][NH2:28]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:11][S:12]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:6]([CH:10]=1)[C:7]([NH:28][CH2:27][C:26]1[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=1[O:24][C:23]([F:22])([F:33])[F:34])=[O:8]

Participants

3

Reactant 2

HCID 2777251(2-(Trifluoromethoxy)phenyl)methanamineHCID 219302755-Bromo-2-(4-chloro-benzenesulfonylamino)-benzoyl chloride

Product 1

HCID 219303005-Bromo-2-(4-chloro-benzenesulfonylamino)-N-(2-trifluoromethoxy-benzyl)-benzamide

Procedure

This compound was prepared using the procedure described in Example 70, using 5-bromo-2-(4-chloro-benzenesulfonylamino)-benzoyl chloride instead of 5-bromo-2-(4-trifluoromethoxy-benzenesulfonylamino)-benzoyl chloride, and 2-trifluoromethoxybenzyl amine instead of 2-methoxy benzyl amine. M/Z of [M−H]−=563.8. 1H NMR (DMSO) δ=4.4 (sd, 2H), 7.3–7.4 (5H), 7.5 (2H), 7.65–7.7 (3H), 7.9–8.0 (1H), 9.4 (br, 1H), 11.5 (br, 1H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2cd2b797c706498281383cab0e79e496
Source dataset
uspto-grants-2006_10
Patent number
US07119120B2

Reaction notes

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