2-Bromoacetamide → HCID 21928068, compound

HRID 1243790Notes

Reaction equation

HRID 1243790 reaction equation
N1CCOCC1.[C:7]([C:9]1[C:14]([CH:15]2[CH2:17][CH2:16]2)=[CH:13][C:12](=[O:18])[NH:11][C:10]=1[SH:19])#[N:8].Br[CH2:21][C:22]([NH2:24])=[O:23]>CN(C=O)C>[C:7]([C:9]1[C:14]([CH:15]2[CH2:16][CH2:17]2)=[CH:13][C:12](=[O:18])[NH:11][C:10]=1[S:19][CH2:21][C:22]([NH2:24])=[O:23])#[N:8]

Participants

4

Reactant 2

HCID 696322-BromoacetamideHCID 21928106HCID 21928106, compound

Product 1

HCID 21928068HCID 21928068, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Cyano-4-cyclopropyl-6-oxo-1,6-dihydro-pyridine-2-thiol morpholine salt (15.00 g, 53.69 mmol) was suspended in 15 mL of dry DMF. 2-Bromoacetamide (7.74 g, 55.0 mmol) was added. This mixture was stirred at room temperature for 30 min and quenched with water. The resultant solid was collected by filtration, washed with water and dried under high vacuum for 24 h to give 2-(3-cyano-4-cyclopropyl-6-oxo-1,6-dihydro-pyridin-2-ylsulfanyl)-acetamide as a pale colored solid (13.22 g, 99%)

Workup

  1. customquenched with water
  2. filtrationThe resultant solid was collected by filtration
  3. washwashed with water
  4. customdried under high vacuum for 24 h

Sources & evidence

ORD record
ord-c27c81c3adca4505900d7f99418d01c3
Source dataset
uspto-grants-2006_10
Patent number
US07119102B2

Reaction notes

Loading…