反应详情

温度

0 °C

2-Phenyl-1H-benzoimidazole-5-carboxylic acid methyl ester (1.178 g, 4.67 mmol) was dissolved in 20 mL THF. Cooled to 0° C. and then added LAH (886 mg, 23.35 mmol). The mixture was heated to 50° C. overnight. Added 0.9 mL water, 0.9 mL 15% NaOH aqu. solution then 3 mL water. Stirred at RT for 30 mins. Filtered through celite and washed the celite with ethyl acetate. Washed the filtrate with brine. Dried over Na2SO4. Filtered and removed solvent in vacuo. Obtained 783 mg (74.8%) of (2-Phenyl-1H-benzoimidazol-5-yl)-methanol as an off white foam.

1. temperatureThe mixture was heated to 50° C. overnight
2. filtrationFiltered through celite
3. washwashed the celite with ethyl acetate
4. washWashed the filtrate with brine
5. dry with materialDried over Na2SO4
6. filtrationFiltered
7. customremoved solvent in vacuo