反应详情

A solution of 2 g of ethyl 6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxylate in 20 cm3 of ethanol and 8.7 cm3 of 1N sodium hydroxide solution are heated for 3 hours at a temperature in the region of 70° C. The ethanol is then removed under reduced pressure to give a solution, which is acidified to a pH in the region of 3 by addition of 1N hydrochloric acid. The resulting mixture is filtered to give 1.48 g of 6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxylic acid in the form of a white solid, the characteristics of which are as follows:

1. customThe ethanol is then removed under reduced pressure
2. customto give a solution, which
3. filtrationThe resulting mixture is filtered