反应详情

温度

20 °C

Starting with a mixture of 1.23 g of 6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxylic acid, 0.26 cm3 of cyclopropylamine, 0.86 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 60 mg of hydroxybenzotriazole in solution in 30 cm3 of dichloromethane, and after stirring for 18 hours at a temperature in the region of 20° C., washing with twice 30 cm3 of distilled water and purifying the crude product obtained by flash chromatography on silica gel (30–70 μm), eluting with a cyclohexane/ethyl acetate (60/40) mixture, 0.58 g of (N-cyclopropyl)-6,6-diphenyl-6,7-dihydro-1H-indazole-3-carboxamide is obtained in the form of a yellow solid, the characteristics of which are as follows:

1. washwashing with twice 30 cm3 of distilled water
2. custompurifying the crude product
3. customobtained by flash chromatography on silica gel (30–70 μm)
4. washeluting with a cyclohexane/ethyl acetate (60/40) mixture