Hydrochloric Acid → HCID 21928677, compound

HRID 1243844Notes

Reaction equation

HRID 1243844 reaction equation
[C:1]1([C:7]2([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:15][C:14]3[N:13](COCC[Si](C)(C)C)[N:12]=[C:11]([C:24]4[CH:28]=[CH:27][S:26][CH:25]=4)[C:10]=3[CH:9]=[CH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C2(C3C=CC=CC=3)CC3NN(COCC[Si](C)(C)C)C(C4C=CSC=4)C=3C=C2)C=CC=CC=1.Cl>C(O)C>[C:29]1([C:7]2([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:15][C:14]3[NH:13][N:12]=[C:11]([C:24]4[CH:28]=[CH:27][S:26][CH:25]=4)[C:10]=3[CH:9]=[CH:8]2)[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21929141HCID 21929141, compoundHCID 21929431HCID 21929431, compound

Product 1

HCID 21928677HCID 21928677, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

But starting with 0.107 g of a mixture of 6,6-diphenyl-3-thiophen-3-yl-1-(2-trimethylsilanylethoxymethyl)-6,7-dihydro-1H-indazole and 6,6-diphenyl-3-thiophen-3-yl-2-(2-trimethylsilanylethoxymethyl)-6,7-dihydro-1H-indazole, 2.2 cm3 of ethanol and 2.2 cm3 of a 2N ethanolic solution of hydrogen chloride. After flash chromatography on a column of silica [eluent: dichloromethane], 0.024 g of 6,6-diphenyl-3-thiophen-3-yl-6,7-dihydro-1H-indazole is thus obtained in the form of a solid, the characteristics of which are as follows:

Sources & evidence

ORD record
ord-98bf3081bb65451b8483b8f20c1ae805
Source dataset
uspto-grants-2006_10
Patent number
US07119115B2

Reaction notes

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