Water → HCID 10955768, compound

HRID 1243958Notes

Reaction equation

HRID 1243958 reaction equation
[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2].[OH2:18]>CS(O)(=O)=O>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([O:7][C:6]2[CH:16]=[CH:17][C:3]([C:1]([NH2:2])=[O:18])=[CH:4][CH:5]=2)=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 962WaterHCID 14902794-(4-methoxyphenoxy)benzonitrile

Product 1

HCID 10955768HCID 10955768, compound

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Procedure

4-(4-Cyanophenoxy)-methoxybenzene (7.66 g, 34 mmol) and water (6.13 g, 340 mmol) in methanesulfonic acid (32.7 g) were heated to 80° C. for 16 hours. The cooled mixture was poured onto ice/water and after stirring for 1 hour the solid was collected and air dried yielding 8.4 g of 4-(4-methoxyphenoxy)benzamideas a white solid. GC-MS (m/z, EI): 243 [M]+.

Workup

  1. additionThe cooled mixture was poured onto ice/water
  2. customwas collected
  3. customair dried
  4. customyielding 8.4 g of 4-(4-methoxyphenoxy)benzamideas a white solid

Sources & evidence

ORD record
ord-fc5824291b5a4724bec697ce5ec4c850
Source dataset
uspto-grants-2006_10
Patent number
US07119201B2

Reaction notes

Loading…