HCID 10311686, compound → HCID 10128797, compound

HRID 1243969Notes

Reaction equation

HRID 1243969 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]1([O:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:32]=[CH:31][N:30]([C:33]5[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=5)[N:29]=4)=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[C:10](=[O:11])[NH:9][C:8](=[O:12])[NH:7][C:6]1=[O:13].Br[C:41]1(CCOCC)C(=O)NC(=O)NC1=O>>[CH2:1]([O:2][CH2:3][CH2:4][C:5]1([O:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:32]=[CH:31][N:30]([C:33]5[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=5)[N:29]=4)=[CH:24][CH:23]=3)=[CH:19][CH:20]=2)[C:6](=[O:13])[NH:7][C:8](=[O:12])[NH:9][C:10]1=[O:11])[CH3:41]

Participants

3

Reactant 2

HCID 10311686HCID 10311686, compoundHCID 219311235-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

Product 1

HCID 10128797HCID 10128797, compound

Procedure

By the same procedure as Example 1, Part C, 4-{4-[1-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-phenoxy}-phenol (from Example 67, Part D) and 5-bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione (from Preparation 3A) were converted to the title compound. MS m/z: ESI+545.3 (M+H)+.

Sources & evidence

ORD record
ord-4af27cba23e54c6692f4fd3fab120785
Source dataset
uspto-grants-2006_10
Patent number
US07119201B2

Reaction notes

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