Methyl 1H-imidazol-1-ylacetate → Imidazole-1-acetic acid

HRID 1244025Notes

Reaction equation

HRID 1244025 reaction equation
C[O:2][C:3](=[O:10])[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1>O>[N:5]1([CH2:4][C:3]([OH:10])=[O:2])[CH:9]=[CH:8][N:7]=[CH:6]1

Participants

3

Reactant 1

HCID 557332Methyl 1H-imidazol-1-ylacetate

Product 1

HCID 656129Imidazole-1-acetic acidYield 97%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Under nitrogen, refluxed 300 mg of imidazol-1-yl-acetic acid methyl ester in 12 ml of H2O for 6 hours. Evaporated in vacuo after cooling to yield 240 mg of white solid (97%) 1H NMR (400 MHz, CD3OD) δ 4.79 (2H, s), 7.41 (1H, s), 7.48 (1H, s), 8.70 (1H, s).

Workup

  1. customEvaporated in vacuo
  2. temperatureafter cooling

Sources & evidence

ORD record
ord-3a5128c9c65f4b478ab52fac33be8a2b
Source dataset
uspto-grants-2006_10
Patent number
US07119207B2

Reaction notes

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