6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbaldehyde → 7-[(6-Ethyl-2-phenyl-piperidin-3-ylamino)-methyl]-6-methoxy-1-methyl-3,4-dihydro-1H-quinolin-2-one

HRID 1244073Notes

Reaction equation

HRID 1244073 reaction equation
[CH2:1]([CH:3]1[NH:8][CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]([NH2:15])[CH2:5][CH2:4]1)[CH3:2].C([C@@H]1N[C@@H](C2C=CC=CC=2)[C@@H](N)CC1)C.C([C@H]1N[C@H](C2C=CC=CC=2)[C@H](N)CC1)C.[CH3:46][O:47][C:48]1[CH:49]=[C:50]2[C:55](=[CH:56][C:57]=1[CH:58]=O)[N:54]([CH3:60])[C:53](=[O:61])[CH2:52][CH2:51]2>>[CH2:1]([CH:3]1[NH:8][CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]([NH:15][CH2:58][C:57]2[CH:56]=[C:55]3[C:50]([CH2:51][CH2:52][C:53](=[O:61])[N:54]3[CH3:60])=[CH:49][C:48]=2[O:47][CH3:46])[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 4

HCID 101251786-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbaldehydeHCID 219316486-Ethyl-2-phenyl-piperidin-3-ylamineHCID 44196399HCID 44196399, compoundHCID 69654712(2R,3R,6R)-6-Ethyl-2-phenyl-piperidin-3-ylamine

Product 1

HCID 219317377-[(6-Ethyl-2-phenyl-piperidin-3-ylamino)-methyl]-6-methoxy-1-methyl-3,4-dihydro-1H-quinolin-2-one

Procedure

By a procedure similar to the previous examples 9 and 9A: prepared through the reaction of 6-ethyl-2-phenyl-piperidin-3-ylamine [or (2S,3S,6S)-6-ethyl-2-phenyl-piperidin-3-ylamine or (2R,3R,6R)-6-ethyl-2-phenyl-piperidin-3-ylamine] with 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carbaldehyde.

Sources & evidence

ORD record
ord-5f8f868177944cf299ff8d532684a7be
Source dataset
uspto-grants-2006_10
Patent number
US07119207B2

Reaction notes

Loading…