反应详情

To a slurry of 3-Benzylamino-3-methyl-butyric acid (1.00 g, 4.83 mmol) in THF was added borane (9.7 mmol, 9.7 mL of a 1.0 M solution in THF). After stirring for 1 h, the mixture was quenched by pouring into a mixture of 1 M HCl and crushed ice. The mixture was neutralized with K2CO3 and extracted 1× with CHCl3. The material was dried via passage through cotton and concentrated to give 441 mg (47%) of the title compound: Rf 0.40 (12:88 MeOH/CHCl3).

1. customthe mixture was quenched
2. additionby pouring into a mixture of 1 M HCl
3. customcrushed ice
4. extractionextracted 1× with CHCl3
5. customThe material was dried via passage through cotton
6. concentrationconcentrated