HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophene-3-boronic acid → 4-Hydroxy-6-oxo-3-(4-thien-3-ylphenyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophene-3-boronic acid | HCID 581760 | — |
| Reactant | 4-Hydroxyphenylboronic acid | HCID 2734360 | — |
| Reactant | 3-(4-Bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile | HCID 54696423 | — |
| Product | 4-Hydroxy-6-oxo-3-(4-thien-3-ylphenyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile | HCID 54718495 | — |
Reaction Steps
Example 109 was prepared from 3-(4-Bromo-phenyl)-4-hydroxy-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carbonitrile (Example 9) using the same procedure as described for Example 189 substituting 3-thiopheneboronic acid for 4-hydroxyphenyl boronic acid. MS (ESI) m/z 350.9 (M+H+); 1H NMR (300 MHz, DMSO-d6) δ ppm 7.91 (dd, 1H), 7.71 (d, 2H), 7.65 (dd, 1H), 7.60 (dd, 1H), 7.45 (d, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07119205B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-8c830c81b3ca4cc8af0e3973a8b8a5be |
| Source note | uspto-grants-2006_10 |