HCID 12020440, compound → HCID 12020441, compound

HRID 1244190Notes

Reaction equation

HRID 1244190 reaction equation
[CH2:1]([CH:4]1[CH2:9][CH2:8][CH:7]([CH:10]2[CH2:15][CH2:14][CH:13]([CH:16]3[CH2:24][C:23]4[C:18](=[C:19]([F:26])[CH:20]=[C:21]([CH3:25])[CH:22]=4)[C:17]3(F)[F:27])[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3].CC([O-])(C)C.[K+]>O1CCCC1>[F:27][C:17]1[C:18]2[C:23](=[CH:22][C:21]([CH3:25])=[CH:20][C:19]=2[F:26])[CH2:24][C:16]=1[CH:13]1[CH2:12][CH2:11][CH:10]([CH:7]2[CH2:8][CH2:9][CH:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6]2)[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 12020440HCID 12020440, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 12020441HCID 12020441, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

10.0 g (0.025 mol) of 4-propyl-4′-(1,1,7-trifluoro-5-methylindan-2-yl)-bicyclohexyl are stirred together with 5.6 g of potassium tert-butylate in 200 ml of tetrahydrofuran at 60° C. for 6 hours. The mixture is then subjected to conventional work-up.

Sources & evidence

ORD record
ord-1b1193db2aa2485ca7b70c40c02006e2
Source dataset
uspto-grants-2006_10
Patent number
US07122228B2

Reaction notes

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