反应详情

温度

0 °C

DIBAL (1N solution in THF, 4 mL) is added to a stirred solution of 6-chloro-4-methoxy-pyridazine-3-carboxylic acid methyl ester (182 mg, 0.9 mmol) in CH2Cl2 (10 mL) cooled to 0° C. The solution is stirred at 0° C. for 3 hours. Excess (Na2SO4).10H2O is then added and the mixture is stirred at room temperature for 45 minutes. The solid is washed with EtOAc, filtered, and the filtrate evaporated in vacuo. The resulting alcohol is used without further purification in the next step.

1. stirringthe mixture is stirred at room temperature for 45 minutes
2. washThe solid is washed with EtOAc
3. filtrationfiltered
4. customthe filtrate evaporated in vacuo
5. customThe resulting alcohol is used without further purification in the next step