Aluminium lithium hydride → HCID 21919289, compound

HRID 1244252Notes

Reaction equation

HRID 1244252 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O:9][C:10]([C:12]1[N:13]=[N:14][C:15]([O:21][CH2:22][CH3:23])=[CH:16][C:17]=1[O:18][CH2:19][CH3:20])=O)C>C1COCC1>[CH2:19]([O:18][C:17]1[CH:16]=[C:15]([O:21][CH2:22][CH3:23])[N:14]=[N:13][C:12]=1[CH2:10][OH:9])[CH3:20]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 58661538Ethyl 4,6-diethoxypyridazine-3-carboxylate

Product 1

HCID 21919289HCID 21919289, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

Lithium aluminum hydride (1N solution in THF, 1 mL) is added to a stirred solution of 4,6-diethoxy-pyridazine-3-carboxylic acid ethyl ester (213 mg, 0.8 mmol) in THF (8 mL) cooled to 0° C. The solution is stirred at 0° C. for 3 hours. Excess Na2SO4-10H2O is then added and the mixture is stirred at room temperature for 45 minutes. The solid is filtered and washed with EtOAc. Evaporation of the filtrate in vacuo provides (4,6-diethoxy-pyridazin-3-yl)-methanol as a light yellow oil, which is used without further purification for the next step.

Workup

  1. stirringthe mixture is stirred at room temperature for 45 minutes
  2. filtrationThe solid is filtered
  3. washwashed with EtOAc
  4. customEvaporation of the filtrate in vacuo

Sources & evidence

ORD record
ord-6d192711d54e42bcba65967d9217b539
Source dataset
uspto-grants-2006_10
Patent number
US07122546B2

Reaction notes

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