反应详情

温度

105 °C

To 35 g of the oil, 2-acetyl-2-propyl-succinic acid diethyl ester, is added concentrated HCl (200 ml). The mixture is refluxed (oil bath 105° C.) overnight and to it is added brine (100 ml). The mixture is extracted with EtOAc (4×150 ml) and the combined extracts are extracted with 2N aqueous NaOH solution (4×100 ml). The NaOH solution is then cooled to 0° C. and acidified with concentrated HCl. The mixture is extracted with EtOAc (4×200 ml) and the combined extracts are washed with brine (200 ml), dried (Na2SO4) and evaporated in vacuo, which provides 3-acetyl-hexanoic acid as a yellow oil.

1. extractionThe mixture is extracted with EtOAc (4×150 ml)
2. extractionthe combined extracts are extracted with 2N aqueous NaOH solution (4×100 ml)
3. temperatureThe NaOH solution is then cooled to 0° C.
4. extractionThe mixture is extracted with EtOAc (4×200 ml)
5. washthe combined extracts are washed with brine (200 ml)
6. dry with materialdried (Na2SO4)
7. customevaporated in vacuo, which