HCID 11305377, compound → HCID 11352458, compound

HRID 1244322Notes

Reaction equation

HRID 1244322 reaction equation
Cl[C:2]1[N:7]=[C:6]2[N:8]([CH2:28][O:29][CH3:30])[C:9]([C:11]3[S:12][C:13]4[C:19]([N:20]5[CH2:25][CH2:24][O:23][CH2:22][CH2:21]5)=[CH:18][CH:17]=[C:16]([O:26][CH3:27])[C:14]=4[N:15]=3)=[N:10][C:5]2=[CH:4][CH:3]=1>N1CCOCC1>[CH3:30][O:29][CH2:28][N:8]1[C:6]2=[N:7][C:2]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:3][CH:4]=[C:5]2[N:10]=[C:9]1[C:11]1[S:12][C:13]2[C:19]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:18][CH:17]=[C:16]([O:26][CH3:27])[C:14]=2[N:15]=1

Participants

3

Reactant 1

HCID 11305377HCID 11305377, compound

Product 1

HCID 11352458HCID 11352458, compoundYield 135.5%

Reagents, catalysts & solvents 1

HCID 8083MorpholineSolvent

Conditions

Temperature
150 °C

Procedure

g 5-Chloro-3-methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridine (0.22 mmol) were dissolved in morpholine (5 ml) in an autoclave and heated to 150° C. for 16 h. The residue was triturated in water whereupon a precipitate formed, which was isolated and dried in vacuo. 0.074 g 3-methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-5-morpholin-4-yl-3H-imidazo[4,5-b]pyridine (66%) were obtained as a yellow solid; M.p.: 126–128° C.

Workup

  1. customThe residue was triturated in water whereupon a precipitate
  2. customformed
  3. customwhich was isolated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-5f803f0c3e0f40d59c2bdbf4455b4af4
Source dataset
uspto-grants-2006_10
Patent number
US07122545B2

Reaction notes

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