Dimethylamine → HCID 178492005, compound

HRID 1244326Notes

Reaction equation

HRID 1244326 reaction equation
Cl[C:2]1[N:7]=[C:6]2[NH:8][C:9]([C:11]3[S:12][C:13]4[C:19]([N:20]5[CH2:25][CH2:24][O:23][CH2:22][CH2:21]5)=[CH:18][CH:17]=[C:16]([O:26][CH3:27])[C:14]=4[N:15]=3)=[N:10][C:5]2=[CH:4][CH:3]=1.[CH3:28][NH:29][CH3:30]>>[CH3:27][O:26][C:16]1[C:14]2[N:15]=[C:11]([C:9]3[NH:8][C:6]4=[N:7][C:2]([N:29]([CH3:30])[CH3:28])=[CH:3][CH:4]=[C:5]4[N:10]=3)[S:12][C:13]=2[C:19]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 178491999HCID 178491999, compound

Product 1

HCID 178492005HCID 178492005, compoundYield 29%

Conditions

Temperature
200 °C

Procedure

0.03 g 5-Chloro-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridine (0.07 mmol) was dissolved in dimethylamine (5 ml) in an autoclave and heated to 200° C. for 16 h. The residue was triturated in water whereupon a precipitate formed, which was isolated and dried in vacuo. 0.08 g [2-(4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-dimethyl-amine (29%) were obtained as a brown solid; M.p.: 120–130° C.

Workup

  1. customThe residue was triturated in water whereupon a precipitate
  2. customformed
  3. customwhich was isolated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-de457baadb4c42d29a6c6ea808263600
Source dataset
uspto-grants-2006_10
Patent number
US07122545B2

Reaction notes

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