反应详情

0.50 g 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carbonitrile and 5.46 ml triethylamine in 13 ml pyridine were stirred for 4 hours with about 5 ml hydrogen sulfide at room temperature. Solvent and excess hydrogen sulfide were removed and the residue chromatographed on siligagel with ethylacetate/heptane 1:1 to yield 0.49 g (87%) 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carbothioic acid amide; M.p.: 238° C.; MS (ISP): m/e=310 (M+H+).

1. customSolvent and excess hydrogen sulfide were removed
2. customthe residue chromatographed on siligagel with ethylacetate/heptane 1:1