HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-azido-5-hydroxyazepane-1-carboxylate → tert-Butyl trans-4-amino-5-hydroxyazepane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-azido-5-hydroxyazepane-1-carboxylate | HCID 58717042 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl trans-4-amino-5-hydroxyazepane-1-carboxylate | HCID 58717039 | 99.5% |
Reaction Steps
6.54 g 4-Azido-5-hydroxy-azepane-1-carboxylic acid tert-butyl ester in 51 ml methanol were hydrogenated in the presence of 0.6 g palladium on charcoal (10%) to yield 5.85 g (quant.) 4-amino-5-hydroxy-azepane-1-carboxylic acid tert-butyl ester as viscous oil; MS (ISP): m/e=231 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122545B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-2144a235c9734536ae1ddbddb1e31a7e |
| Source note | uspto-grants-2006_10 |