2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 136122457, compound

HRID 1244389Notes

Reaction equation

HRID 1244389 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@@H:9]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[CH3:10])[CH:5]=[N:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[C:24](B2OC(C)(C)C(C)(C)O2)[CH:23]=[CH:22][C:21]=1[OH:35]>>[CH3:18][O:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([NH:8][C@@H:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[CH3:10])[N:7]=2)[CH:23]=[CH:22][C:21]=1[OH:35]

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 587171106-Chloro-N-[(1R)-1-(4-methylphenyl)ethyl]pyrazin-2-amine

Product 1

HCID 136122457HCID 136122457, compoundYield 6.5%

Procedure

In a procedure analogous to Example 2, reaction of 6-chloro-N-[(1R)-1-(4-methylphenyl)ethyl]pyrazin-2-amine (56.8 mg, 0.229 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 63 mg, 0.25 mmol) furnished the product (5 mg, 6%).

Sources & evidence

ORD record
ord-2380ab7bc2264ceaa04cee7f3f21bec1
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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