HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanecarbonyl chloride → N-[4-(6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl)phenyl]cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanecarbonyl chloride | HCID 77637 | — |
| Reactant | 6-(4-aminophenyl)-N-[(1S)-1-phenylethyl]pyrazin-2-amine | HCID 58717093 | — |
| Product | N-[4-(6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl)phenyl]cyclopropanecarboxamide | HCID 58717100 | — |
Reaction Steps
In a method analogous to that reported in example 39, reaction of 6-(4-aminophenyl)-N-[(1S)-1-phenylethyl]pyrazin-2-amine (58 mg, 0.2 mmol) and cyclopropanecarbonyl chloride (25 mg, 0.24 mmol) furnished the pure product after chromatographic purification using ethyl acetate-hexane (3:2) (46 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122550B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-bc63b730961541b48bb1e97fefadb5bc |
| Source note | uspto-grants-2006_10 |