Phenylglyoxal → 3-(4-Fluoro-benzyl)-7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine

HRID 1244635Notes

Reaction equation

HRID 1244635 reaction equation
O=[C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:3]=O.[F:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][C:17]2[N:18]([NH2:23])[C:19]([NH2:22])=[N:20][N:21]=2)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:25]=[CH:24][C:15]([CH2:16][C:17]2[N:18]3[N:23]=[CH:3][C:2]([C:5]4[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=4)=[N:22][C:19]3=[N:20][N:21]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 14090PhenylglyoxalHCID 219193225-[(4-Fluorophenyl)methyl]-4H-1,2,4-triazole-3,4-diamine

Product 1

HCID 219193173-(4-Fluoro-benzyl)-7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine

Procedure

General procedure A was followed with the reaction of oxo-phenyl-acetaldehyde and 5-(4-fluoro-benzyl)-[1,2,4]triazole-3,4-diamine to provide 3-(4-fluoro-benzyl)-7-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine and the desired product 3-(4-fluoro-benzyl)-6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazine (example 4).

Sources & evidence

ORD record
ord-61c720a8e1f049ccae42ee87b9b460c5
Source dataset
uspto-grants-2006_10
Patent number
US07122548B2

Reaction notes

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