2-Oxo-2-(thiophen-2-yl)acetaldehyde → 3-(4-Fluoro-benzyl)-7-thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazine

HRID 1244636Notes

Reaction equation

HRID 1244636 reaction equation
O=[C:2]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)[CH:3]=O.[F:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[N:17]([NH2:22])[C:18]([NH2:21])=[N:19][N:20]=2)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[N:17]3[N:22]=[CH:3][C:2]([C:5]4[S:6][CH:7]=[CH:8][CH:9]=4)=[N:21][C:18]3=[N:19][N:20]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 52722142-Oxo-2-(thiophen-2-yl)acetaldehydeHCID 219193225-[(4-Fluorophenyl)methyl]-4H-1,2,4-triazole-3,4-diamine

Product 1

HCID 219193143-(4-Fluoro-benzyl)-7-thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazine

Procedure

General procedure A was followed with the reaction of oxo-thiophen-2-yl-acetaldehyde and 5-(4-fluoro-benzyl)-[1,2,4]triazole-3,4-diamine to provide 3-(4-fluoro-benzyl)-7-thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazine and 3-(4-fluoro-benzyl)-6-thiophen-2-yl-[1,2,4 ][triazolo 1,2,4,-b][1,2,4]triazine (example 5).

Sources & evidence

ORD record
ord-e930fc685e644cfeb3e55267d405ad9f
Source dataset
uspto-grants-2006_10
Patent number
US07122548B2

Reaction notes

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