2-(4-Bromophenyl)-2-oxoacetaldehyde → 6-(4-Bromo-phenyl)-3-(4-fluoro-benzyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine

HRID 1244637Notes

Reaction equation

HRID 1244637 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=O)=[CH:4][CH:3]=1.[F:12][C:13]1[CH:26]=[CH:25][C:16]([CH2:17][C:18]2[N:19]([NH2:24])[C:20]([NH2:23])=[N:21][N:22]=2)=[CH:15][CH:14]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:24][N:19]3[C:18]([CH2:17][C:16]4[CH:25]=[CH:26][C:13]([F:12])=[CH:14][CH:15]=4)=[N:22][N:21]=[C:20]3[N:23]=2)=[CH:4][CH:3]=1.[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:23][C:20]3[N:19]([C:18]([CH2:17][C:16]4[CH:25]=[CH:26][C:13]([F:12])=[CH:14][CH:15]=4)=[N:22][N:21]=3)[N:24]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2335862-(4-Bromophenyl)-2-oxoacetaldehydeHCID 219193225-[(4-Fluorophenyl)methyl]-4H-1,2,4-triazole-3,4-diamine

Product 2

HCID 114519126-(4-Bromo-phenyl)-3-(4-fluoro-benzyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazineHCID 219193247-(4-Bromo-phenyl)-3-(4-fluoro-benzyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine

Procedure

General procedure A was followed with the reaction of (4-bromo-phenyl)-oxo-acetaldehyde and 5-(4-fluoro-benzyl)-[1,2,4]triazole-3,4-diamine to provide 7-(4-bromo-phenyl)-3-(4-fluoro-benzyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine and 6-(4-bromo-phenyl)-3-(4-fluoro-benzyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazine (example 5).

Sources & evidence

ORD record
ord-b4f892dfe4234f30a77ff6520578667a
Source dataset
uspto-grants-2006_10
Patent number
US07122548B2

Reaction notes

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