Sodium Hydroxide → HCID 21920819, compound

HRID 1244674Notes

Reaction equation

HRID 1244674 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][C:3]=1[NH:13][C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:15].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[NH:13][C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21920762HCID 21920762, compound

Product 1

HCID 21920819HCID 21920819, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.98 mmol (990 mg) of methyl 4-chloro-3-[[(phenylamino)carbonyl]-amino]benzeneacetate is taken up in 10 ml of methanol and mixed with 6 mmol of 1N NaOH. After 2 hours of stirring at room temperature, the methanol is distilled off, and the residue is acidified with 1 M HCl to pH 2–3. It is extracted with ethyl acetate, dried with Na2SO4, and solvent is removed. Recrystallization is carried out from boiling isopropanol. Yield: 830 mg of white solid 4.

Workup

  1. distillationthe methanol is distilled off
  2. extractionIt is extracted with ethyl acetate
  3. dry with materialdried with Na2SO4, and solvent
  4. customis removed
  5. customRecrystallization

Sources & evidence

ORD record
ord-232aa08ee3d042ae9d6e7aa95bd5a296
Source dataset
uspto-grants-2006_10
Patent number
US07122570B2

Reaction notes

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