Sodium Hydroxide → HCID 21920819, compound

Participants

Reaction Steps

2.98 mmol (990 mg) of methyl 4-chloro-3-[[(phenylamino)carbonyl]-amino]benzeneacetate is taken up in 10 ml of methanol and mixed with 6 mmol of 1N NaOH. After 2 hours of stirring at room temperature, the methanol is distilled off, and the residue is acidified with 1 M HCl to pH 2–3. It is extracted with ethyl acetate, dried with Na2SO4, and solvent is removed. Recrystallization is carried out from boiling isopropanol. Yield: 830 mg of white solid 4.

Provenance & Evidence