HCID 68619724, compound → HCID 11291335, compound

HRID 1244691Notes

Reaction equation

HRID 1244691 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH:25]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][C:27]2=[O:32])[CH2:24][N:11]2[CH2:12][CH2:13][C:14]3[C:19]([CH:10]2[CH2:9]1)=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=3)(C)(C)C>C(O)C.CCCCCCC>[NH2:7][C@H:8]1[C@H:25]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][C:27]2=[O:32])[CH2:24][N:11]2[CH2:12][CH2:13][C:14]3[C:19]([C@H:10]2[CH2:9]1)=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=3

Participants

3

Reactant 1

HCID 68619724HCID 68619724, compound

Product 1

HCID 11291335HCID 11291335, compound

Reagents, catalysts & solvents 1

HCID 22502148Ethanol heptaneSolvent2×

Procedure

(RS,RS,RS)-[9,10-Dimethoxy-3-(2-oxo-piperidin-1-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl]-carbamic acid tert-butyl ester (580 mg, 1.61 mmol) was dissolved in ethanol/heptane 3:2 (5 mL) and subjected to preparative HPLC (Chiralpak® AD column, heptane/ethanol 80:20).

Sources & evidence

ORD record
ord-b6aee979175f4432b18d59fdd310c2e9
Source dataset
uspto-grants-2006_10
Patent number
US07122555B2

Reaction notes

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