HCID 11291335, compound → HCID 11337326, compound

HRID 1244692Notes

Reaction equation

HRID 1244692 reaction equation
[NH2:1][C@H:2]1[C@H:19]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][C:21]2=[O:26])[CH2:18][N:5]2[CH2:6][CH2:7][C:8]3[C:13]([C@H:4]2[CH2:3]1)=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=3>CCCCCCC.C(O)C>[NH2:1][C@@H:2]1[C@@H:19]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][C:21]2=[O:26])[CH2:18][N:5]2[CH2:6][CH2:7][C:8]3[C:13]([C@@H:4]2[CH2:3]1)=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH3:17])[CH:9]=3

Participants

3

Reactant 1

HCID 11291335HCID 11291335, compound

Product 1

HCID 11337326HCID 11337326, compound

Reagents, catalysts & solvents 1

HCID 22502148Ethanol heptaneSolvent2×

Procedure

Light yellow semisolid, 220 mg (38%), tR=32.0 min (Chiralpak® AD 25×0.46 cm, heptane/ethanol 80:20, flow rate 1 mL/min). (+)-(R,R,R)-1-(2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido [2,1-a]isoquinolin-3-yl)-piperidin-2-one: Light yellow semisolid, 207 mg (36%), tR=55.4 min (Chiralpak® AD 25×0.46 cm, heptane/ethanol 80:20, flow rate 1 mL/min).

Sources & evidence

ORD record
ord-1528c565d17941e681853c7e34cf333d
Source dataset
uspto-grants-2006_10
Patent number
US07122555B2

Reaction notes

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